Another efficacious and popular treatment for chronic depressive episodes is Tianeptine, which has been claimed to be on equal par with amitriptyline, imipramine and fluoxetine. The edge that Tianeptine has over these other antidepressants is that it can boast significantly fewer side effects, which is a heavy punch line when health security is at stake here. We are suppliers of antidepressant tianeptine and if you are looking for an online pharmacy to purchase Medications, you should give this one a try, as we have had positive experiences making purchases here.
Tianeptine with Depression and Anxiety
In addition to causing fewer side effects than other antidepressants that are more or less comprable with it, tianeptine has shown more efficacy than maprotiline.
This was confirmed in a number of people who had both depression and anxiety co-existing together at the same time.
It has also been found that tianeptine has a much stronger anxiolytic clout and has been beneficial in the treatment of a whole bunch of anxiety disorders that also include panic disorder.
This was highlighted in a study which confirmed this medication’s ability to block panic disorder.
Tianeptine has also been equated with many other antidepressants such as bupropion, the selective serotonin reuptake inhibitors, the serotonin-norepinephrine reuptake inhibitors, moclobemide and many other antidepressants.
Tianeptine has also been reputed as having a positive and beneficial effect on cognition abilities in people who have depression-induced cognitive dysfunction.
In 2005, a research study in Egypt confirmed the efficacy of tianeptine in men who suffered from depression and erectile dysfunction.
To cap it off, the efficacy of tianeptine has been found in the treatment of depression, in patients with Parkinson’s disease and for post-traumatic stress disorder.
For the treatment of this disorder, tianeptine was found to be just as efficacious as fluoxetine and moclobemide.
More Uses
A clinical trial on the treatment of irritable bowel syndrome was carried out in to compare the efficacy and tolerability with amitriptyline showed tianeptine to be just as effective as amitriptyline.
Even so, tianeptine produced fewer adverse side effects such as dry mouth and constipation.
For the treatment of asthma tianeptine was also found to be very efficacious.
This was confirmed following the published results of a 52 week randomized controlled trial of asthmatic children that was carried out in 1998.
The children who received tianeptine had a sharp reduction in their clinical rating and boosted lung function.
Being the only agent known to reduce free serotonin in plasma and at the same time enhance uptake in platelets, tianeptine was used to find if reducing free serotonin levels in plasma would help improve asthma in the children with the condition.
Subsequent clinical trials that involved just under 25,000 participants which lasted for a period of seven years showed that tianeptine was able to reduce free serotonin in plasma and improve the condition of asthmatic children.
Additionally, tianeptine is also endowed with anticonvulsant and analgesic properties.
In a recent clinical trial conducted in Spain that ended in 2007, the efficacy of tianeptine in the treatment of pain caused by fibromyalgia was confirmed.
Likewise for the treatment of attention-deficit hyperactivity disorder, the efficacy of tianeptine has once again been clearly proven, with minimal side effects.
Tianeptine Side Effects
When compared with other tricyclic antidepressants, it becomes clear that this medication produces substantially fewer cardiovascular, anticholinergic (such as dry mouth and constipation), sedative as well as effects of an appetite-stimulating nature.
One possible blotch on this otherwise untarnished status of tianeptine comes from a recent review which found, albeit the evidence to support this claim was of dubious quality, that tianeptine was one among other antidepressants that caused hepatotoxicity (liver damage).
As for the claim that tianeptine may have an effect on heart function, there’s no tangible evidence in support of such a claim, while other antidepressants do affect heart function.
At especially high doses, both opioid receptor agonists and tianeptine may sometimes give rise to euphoria, but these doses are well above the normal range of treatment doses.
It’s also medically known that tianeptine can cause severe withdrawal symptoms following prolonged use at high doses which of necessity should usher in an urgent feeling of extreme caution.
Side Effects by Frequency
Common side effects of tianeptine (>1% frequency)
- Insomnia/nightmares (up to 20%)
- Dry mouth (up to 20%)
- Headache (up to 18%)
- Constipation (up to 15%)
- Dizziness (up to 10%)
- Drowsiness (up to 10%)
- Weight gain (~3%)
- Nausea
- Abdominal pain
- Agitation
- Anxiety/irritability
Uncommon Side Effects of Tianeptine (0.1-1% frequency)
- Tremor
- Bitter taste
- Hot flushes
- Flatulence
- Palpitations
- Gastralgia
- Micturition disturbances
- Blurred vision
- Premature ventricular contractions
- Muscle aches
Rare Side Effects of Tianeptine (<0.1-1% frequency)
- General fatigue
- Hepatitis
- Protracted muscle aches
- Hypomania
- Pruritus/allergic-type skin reactions
- Euphoria
- ECG changes
Atypical μ-opioid receptor agonist
Researchers found in 2014 that tianeptine was a μ-opioid receptor (MOR) full agonist using human proteins.
Similarly, it was found to actually act as a full agonist of the δ-opioid receptor (DOR) although its potency was 200 times lower in this role.
The researchers later found that in mice, the MOR agonist was needed for the acute and chronic antidepressant-like effects of tianeptine and because its primary metabolite had the same action as a MOR agonist though it had a much longer elimination half-life.
It was also found that although tianeptine was able to produce other opioid-like effects such as analgesia and reward, it didn’t result in tolerance or withdrawal.
From this, researchers suggested that tianeptine may actually be behaving as a biased agonist of the MOR which may be responsible for its atypical status as an MOR agonist.
Nevertheless, some reports have suggested that withdrawal symptoms that resemble those of other known opioids that can also cause depression, insomnia and cold/flu-like symptoms, do occur after prolonged use on doses that are well above the range that are medically permitted.
Actions of Tianeptine in Involved Processes
Research results have suggested that tianeptine produces antidepressant effects through changes and inhibitions of the glutamate receptor activity that involves AMPA receptors and NMDA receptors, as well affect neural plasticity as the release of BDNE, which in turn, affects neural plasticity.
Some researchers have also hypothesized that tianeptine may have a protective impact against neuronal remodeling which is induced by stress.
There is also the fact that tianeptine can act on the NMDA and AMPA receptors.
Tianeptine may also facilitate the transfer or transport of signals by changing the phosphorylation state of glutamate receptors.
With the fast and new effects of antidepressant drugs such as ketamine, many people believe that the efficacy of antidepressants such as tianeptine is associated with the promotion of synaptic plasticity.
This however can only be achieved by controlling the excitatory nature of amino acid systems that cause changes in the strength of synaptic connections and for enhancing BDNE activity, keeping in mind that these findings are mainly based on preclinical studies.
Takeaway
Despite the fact that there’s still more ground to cover on the subject of the curative properties of tianeptine, what has been written does give a very detailed account of what this medication is capable of treating with the aid of other agents. No doubt you have benefited from your read and we are extra pleased to inform you that you can find this antidepressant medication for treating your chronic depression right here on this website.
