Usually sold under the brand name Dostinex among other brand names, Cabergoline is medically known as a dopaminergic medication that’s used for the treatment of high prolactin levels, prolactinomas, Parkinson’s disease, and other conditions for which the medication is indicated to treat. This drug medication is normally taken by mouth and we are very pleased, as suppliers of this medication to inform that you can find this drug medication on this this very website.
Medical Uses
The following are some of the ways Cabergoline is used in the treatment of some conditions as follows:
- Suppression of lactation;
- Hyperprolactinemia;
- Adjunctive treatment of pituitary gland tumors that produce prolactin (prolactinomas);
- Treatment of Parkinson’s disease in its early stage of development;
- Taken in combination with levodopa and a decarboxylase inhibitor such as carbidopa for treating, progressive-phase of Parkinson’s disease;
- In some counties, the treatment of ablactation and dysfunctions associated with hyperprolactinemia (amenorrhea, oligomenorrhea, anovulation, nonpuerperal mastitis and galactorrhea);
- Uterine fibroids;
- As an adjunctive in the therapy of acromegaly, cabergoline has a low efficacy in preventing hormone growth levels but is known to be very effective in stopping the growth of hyperprolactinemia that occur in 20 – 30% of acromegaly cases;
- Hormone growth and prolactin are essentially similar in structure and cause the same side effects in many body tissues that are targeted. Therefore
It’s also medically known that cabergoline is often used to act as a first-line medication in the management of prolactinomas
This is so because of its greater connection with D₂ receptor locations, reduced strength of side effects, and more convenient dosing schedules than bromocriptine which is an older medication.
Despite this, promocriptine is still more popular in pregnancy due to the dearth of data on the safety of usage for cabergoline during pregnancy.
Using Cabergoline as Off-Label Medication
It’s also medically known that sometimes cabergoline has been added (adjunct) to SSRI antidepressants due to its ability to counteract some side effects of such drug medications.
These side effects include reduction in sexual urge (libido) and anorgasmia.
Some have suggested that this medication does have a recreational usage that reduces or totally eliminates the refractory period in males.
This permits men to enjoy a series of ejaculatory orgasms in fast succession; speculations that has the support of two scientific studies.
In addition, a meta-analysis and a systematic review both concluded that the treatment with prophylactic cabergoline has the effect of reducing this occurrence.
However, the same treatment doesn’t seem to have the same efficacy for the treatment of ovarian hyper-stimulation syndrome (OHSS), without adversely affecting birth outcomes in women experiencing the stimulated cycles of in vitro fertilization (IVF).
Effects during Pregnancy and Lactation
Not much is known about the impacts of this medication during pregnancy and lactation, however, in some instances, the similar bromocriptine medication may act as an optional choice when pregnancy is expected to take place as discussed below:
Pregnancy: initial data available seem to indicate a somewhat increased rate of congenital or birth defects (abnormalities) in women patients who get pregnant while taking cabergoline as a treatment.
Nevertheless, a study reached the conclusion that “foetal exposure to cabergoline during early pregnancy does not induce any increase in the risk of miscarriage or foetal malformation.
Lactation: research trials on rats using cabergoline found that this medication had the propensity to pass into breast milk. However the possibility that this process can also take place in humans has not been confirmed.
Nevertheless it has been the known practice that breastfeeding shouldn’t be practiced by women if, or when treatment with cabergoline is essential for the women in question.
Suppression of lactation: Countries sometimes use cabergoline (Dostinex) as a treatment for suppressing lactation. Sometimes also, it’s used in veterinary medication for the treatment of false pregnancy in dogs.
Contraindications
It’s ill-advised to use cabergoline for the treatment of:
- Hypersensitivity to ergot derivatives
- Child (pediatric) patients with no clinical experience
- Patients with severe impairment of liver function or cholestasis
- Combined use with other drug medications especially those drugs metabolized by CYP450 enzymes such as erythromycin and ketoconazole, due to the fact that increased levels of cabergoline plasma may occur (even though this medication does undergo minimal CYP450 metabolism).
- Precautions: especially for the treatment of severe cardiovascular disorders, Raynaud’s disease, gastroduodenal ulcers, active gastrointestinal bleeding, and hypotension.
Cabergoline Side Effects
Most of the side effects of this drug medication are dose related.
More severe adverse effects have been reported for the treatment of Parkinson’s disease and for the treatment of restless leg syndrome with cabergoline both of which normally require very high doses.
However, when this medication is taken for the treatment of hyperprolactinemia, the side effects caused are usually mild.
This is also the case with the treatment of gynecological indicators or endocrine disorders where the usual dose is about one hundredth to a tenth of the dose required for treating Parkinson’s disease.
Normally, cabergoline needs a slow dose titration which would take a period of 2 to 4 weeks for hyperprolactinemia (often much longer for the other conditions), for minimizing the risk of side effects.
Usually the very long duration for this medication to be absorbed by the body may interfere and complicate the dosing schedule during titration and extra precautionary measures may be needed
Nevertheless, cabergoline is regarded the best tolerable option for the treatment of hyperprolactinemia even though the novel and not properly tested quinagolide may offer nearly the same favorable side effect image with a quicker times for titration.
Clinical Study on Cabergoline Side Effects
A clinical study was conducted on about 200 participants who were diagnosed with Parkinson’s disease to determine intensity of the side effects of cabergoline with the following results. The side effects were mostly mild or moderate in intensity as follows:
- Gastrointestinal tract – here, side effects were highly frequent. A total of 53 percent of patients reported they experienced side effects with the following symptoms and frequencies:
- Nausea (30 %)
- Constipation (22%)
- Dry mouth (10%)
- Gastric irritation (7%)
- Vomiting (5%), and
- Dyspepsia (2%)
- Psychiatric and central nervous system (CNS) – this group numbered 51% of patients affected with the following symptoms and frequencies:
- Somnolence (18%)
- Insomnia (11%)
- Vertigo (27%)
- Depression (13%)
- Dyskinesia (4%)
- Hallucinations (4%)
- Cardiovascular – About 30% of patients experienced side effects, with the following symptoms and frequencies:
- Hypotension – (10%)
- Peripheral edema (14%) and non-specific edema (2%)
- Arrhythmias was experienced by 4.8%
- Palpitations (4.3%)
- Angina pectoris (1.4%)
Takeaway
The production and effective use of cabergoline has been an amazing achievement of the medical profession in its tireless effort to produce a multi-purpose medication that can treat a whole range of conditions with a very low incidence of side effects. The range of conditions that cabergoline can treat is self-evident in what has been written in this article and If you are looking for an online pharmacy to purchase Medications, you should give this one a try, as we have had positive experiences making purchases here.
